Mean Electrostatic Flux on AChE's Gorge
The figure
shows a portion of the molecular surface associated with
the active site gorge in full detail. The remaining part of HuChE is outlined.
The arrows represent the mean value of the electrostatic flux on a square
grid (20A X 20A) positioned at the top of the gorge mouth and 16A
away from the C-alpha of W286.
The large arrow (0.083 kT*A/e) corresponds to the wild type HuChE while
small arrow (0.019 kT*A/e ) represents the mean electrostatic flux of
the M7 mutant.