Positive Selection in evolution of Listeria monocytogenes inlA

Research in Prof. Wiedmann’s laboratory focuses on the molecular pathogenesis, ecology, epidemiology evolution, and transmission of bacterial and foodborne diseases with a particular focus on two foodborne pathogens, Listeria monocytogenes and Salmonella.

Reference to our collaborative work:

R.H. Orsi, D.R. Ripoll, M. Yeung, K.K. Nightingale, and M. Wiedmann (2007). “Recombination and positive selection contribute to evolution of Listeria monocytogenes inlA”. Microbiology, 153, 2666-2678 [pdf]

Here is a link to a short movie showing the molecular surface of the internalin structure with a interesting and well-defined distribution of charged residues.

Positive Selection in evolution of Listeria monocytogenes inlA

Research in Prof. Wiedmann’s laboratory focuses on the molecular pathogenesis, ecology, epidemiology evolution, and transmission of bacterial and foodborne diseases with a particular focus on two foodborne pathogens, Listeria monocytogenes and Salmonella.

Here is a link to a short movie showing the molecular surface of the internalin structure with a interesting and well-defined distribution of charged residues.

Residues are colored as follows:

blue: positively-charged

red: negatively-charged

yellow: hydrophobic

pink: polar