This project was carried out as a collaborative effort with C. H. Faerman
(Biochemistry and Molecular Biology, Cornell-USA),
Richard Gillilan ( MacCHESS, Cornell-USA),
I. Silman and collaborators (Weizmann Institute-Israel),
J. Sussman and collaborators
(Weizmann Institute-Israel, and Brookhaven National Laboratory-USA),
J. A. McCammon and collaborators (Univ. of Houston-USA),
J. Massoulie and collaborators
(Ecole Normale Superieure, France).
Publications:
`` Site-direct mutants designed to test back-door hyphotheses
of acetylcholinesterase function.'' C. H. Faerman,
D. R. Ripoll, S. Bon., Y. Le Feuvre, N. Morel, J. Massoulie, J. Sussman,
I. Silman. (1996) FEBS letters386, 65-71.
``Electrostatic Properties of Human
Acetylcholinesterase.'' D. R. Ripoll, C. H. Faerman, R. Gillilan,
I. Silman and J. L.Sussman. In Enzymes of the Cholinesterase Family.
(1995). D. M. Quinn, A. S. Balasubramanian, B. P. Doctor and P. Taylor,
eds. Plenum Press, NY. pp. 67-70.
`` Visualizing Enzyme Electrostatics with IBM Visualization Data Explorer".
R. Gillilan and D. Ripoll, (1994). In `` Data Visualization in Molecular
Science.'' J. Bowie Ed. Manning Publications Co. and Addison-Wesley
Publishing Company Inc. Chapter 4, pp. 61-81.
``Open Back Door in a Molecular Dynamics
Simulation of Acetylcholinesterase.'' M. Gilson, T. Straatsma, J.A. McCammon,
D. Ripoll, C. Faerman, P. Axelsen, I. Silman and J. Sussman. (1994)
Science 263, 1276.
``An Electrostatic Mechanism for Substrate Guidance
Down the Aromatic Gorge of Acetylcholinesterase." D. Ripoll, C. H. Faerman, P. Axelsen,
I. Silman and J. Sussman. (1993) Proc. Natl. Acad. Sci. USA
90, 5128-5132.
See a nice video on AChE, made by
Richard Gillilan, choose one from the next line.
(mpeg loops:
9.87 Mbyte ,
2.85 Mbyte ,
1.89 Mbyte) 
